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Background Smoking is a significant health concern, associated with several severe medical conditions, including systemic inflammation, cancers, cardiovascular diseases (CVDs), respiratory infections, and endothelial dysfunction

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Introduction Peripheral artery disease (PAD) is a major cardiovascular disease that affects more than 200 million people worldwide and an estimated 8.5 million people in the U.S ( Smoking contributes to the clinical expression of PAD and smoking cessation has clear clinical benefits